Study of the roles of caspase-3 and nuclear factor kappa B in myenteric neurons in a P2X7 receptor knockout mouse model of ulcerative colitis

doi:10.3748/wjg.v29.i22.3440

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World Journal of Gastroenterology

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1007-9327

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World J Gastroenterol. Jun 14, 2023; 29(22): 3440-3468
Published online Jun 14, 2023. doi: 10.3748/wjg.v29.i22.3440

Table 4 Macroscopic and microscopic lesions in the distal colon of ulcerative colitis model mice and mice that received intrarectal injection of 35% ethanol

Groups	Macroscopic injury	Microscopic injury
Groups	Macroscopic injury	Ulcer	Submucosal edema	Inflammatory cell infiltration
WT sham 24 h	0.0 ± 0.0^NS	0.0 ± 0.0^NS	0.8 ± 0.2^NS	1.2 ± 0.2^NS
WT colitis 24 h	1.0 ± 0.0^NS	0.0 ± 0.0^NS	1.6 ± 0.2^NS	2.0 ± 0.2^NS
KO sham 24 h	0.0 ± 0.0^NS	0.0 ± 0.0^NS	0.8 ± 0.2^NS	1.0 ± 0.0^NS
KO colitis 24 h	0.4 ± 0.1^NS	0.0 ± 0.0^NS	0.8 ± 0.4^NS	1.2 ± 0.2^NS
WT sham 4 d	0.0 ± 0.0^NS	0.0 ± 0.0^NS	1.0 ± 0.2^NS	1.0 ± 0.0^NS
WT colitis 4 d	0.5 ± 0.2^NS	0.0 ± 0.0^NS	1.0 ± 0.0^NS	1.2 ± 0.2^NS
KO sham 4 d	0.0 ± 0.0^NS	0.0 ± 0.0^NS	0.6 ± 0.2^NS	0.4 ± 0.2^NS
KO colitis 4 d	0.0 ± 0.0^NS	0.0 ± 0.0^NS	0.8 ± 0.2^NS	0.4 ± 0.2^NS

The presence of ulcers, severity of edema in the submucosal layer, and degree of inflammatory cell infiltration were assessed by histological analysis. NS: Not significant; WT: Wild-type; KO: Knockout.

Citation: Magalhães HIR, Machado FA, Souza RF, Caetano MAF, Figliuolo VR, Coutinho-Silva R, Castelucci P. Study of the roles of caspase-3 and nuclear factor kappa B in myenteric neurons in a P2X7 receptor knockout mouse model of ulcerative colitis. World J Gastroenterol 2023; 29(22): 3440-3468
URL: https://www.wjgnet.com/1007-9327/full/v29/i22/3440.htm
DOI: https://dx.doi.org/10.3748/wjg.v29.i22.3440