Fibroblast growth factor 15, induced by elevated bile acids, mediates the improvement of hepatic glucose metabolism after sleeve gastrectomy

Figure 4 Farnesoid X receptor- fibroblast growth factor 15-fibroblast growth factor receptor 4 were stimulated and hepatic gluconeogenesis were depressed after sleeve gastrectomy. The mRNA relative expression of ileal fibroblast growth factor (FGF) 15, farnesoid X receptor, and hepatic glucose-6-phosphatase, phosphoenolpyruvate carboxykinase and fibroblast growth factor receptor 4 in SHAM and sleeve gastrectomy (SG) group at week 12 postoperation. ^aP < 0.05, ^bP < 0.01, ^cP < 0.001, SG vs SHAM group. SG: Sleeve gastrectomy; FXR: Farnesoid X receptor; FGF: Fibroblast growth factor; FGFR4: Fibroblast growth factor receptor 4; Pepck: Phosphoenolpyruvate carboxykinase; G6Pase: Glucose-6-phosphatase.