Peutz-Jeghers syndrome without STK11 mutation may correlate with less severe clinical manifestations in Chinese patients

Table 5 Comparison of clinicopathological parameters between two groups

Project	Wild-type (n = 19)	Mutant-type (n = 73)	P value
Gender
Male	11	44	0.851
Female	8	29
Family history
No	13	51	0.903
Yes	6	22
ABO blood group1
A	7	23	0.964
B	6	21
AB	4	18
O	2	9
Rh blood group1
Negative	0	0
Positive	19	71
Age of initial treatment (years)	18.474 ± 8.8089	12.973 ± 8.3881	0.021
Final age of follow-up (years)	30.842 ± 11.3101	27.425 ± 9.7680	0.239
Total hospitalizations	3 (1, 4)	4 (3, 6)	0.003
Age of first intussusception (years)	22 (14, 27)	15 (9.25, 24)	0.025
Frequency of intussusception	1 (1, 2)	2 (1, 3)	0.006
Age of initial surgery (years)	19 (14, 25)	14 (8, 23.75)	0.007
Number of operations	1 (1, 2)	1 (1, 2)	0.924
Age of mucocutaneous pigmentation appearance (years)	3 (0, 5)	3 (0.5, 5)	0.811
Order of mucocutaneous pigmentation appearance
Lips	2	17	0.213
Lips and limbs	1	46
Lips to limbs	16	10
Time interval from mucocutaneous pigmentation appearance to abdominal symptoms (years)	14.5 (8, 25.5)	10 (5, 15)	0.038
Distribution of gastric polyps
Yes	16 (84.2%)	60 (82.2%)	1
No	3 (15.8%)	13 (17.8%)
Load of gastric polyps	5 (5, 10)	5 (3.25, 10)	0.111
Maximum diameter of gastric polyps (mm)	7 (4.25, 10)	10 (6, 15)	0.012
Distribution of duodenal intestine polyps
Yes	18 (94.7%)	71 (97.3%)	1
No	1 (5.3%)	2 (2.7%)
Load of duodenal intestine polyps	3 (1, 6.5)	7 (4, 15.5)	0.013
Maximum diameter of duodenal intestine polyps (mm)	30 (15, 50)	48 (30, 60)	0.110
Distribution of colorectal polyps
Yes	6 (31.6%)	52 (71.2%)	0.001
No	13 (68.4%)	21 (28.8%)
Load of colorectal polyps	4 (1.5, 12)	3 (1, 10)	0.864
Maximum diameter of colorectal polyps (mm)	30 (15, 50)	25 (13.5, 40)	0.664
Carcinogenesis
Yes	0 (0%)	9 (9.52%)	0.239
No	19 (100%)	64 (90.48%)
Pathology of polyps
Hamartoma	12	35	0.344
Adenoma	2	8
Hamartoma + adenoma	2	4
Carcinogenesis	0	9
Deletion	3	17
Times of endoscopic examinations	2 (1, 2)	2 (2, 4.75)	0.012

¹A few cases did not undergo relevant laboratory tests.