Ineffective esophageal motility is associated with acute rejection after lung transplantation independent of gastroesophageal reflux

Table 2 Cox univariate and multivariable analyses demonstrating the association between manometric diagnosis of ineffective esophageal motility as defined by CCv3.0 and acid reflux based on acid exposure time > 4.2%, and increased risk of acute rejection after lung transplantation

Covariate	Cox univariate analysis	P value	Cox multivariable analysis	P value
Ineffective esophageal motility	1.84 (1.03-3.30)	0.04	2.20 (1.18-4.11)	0.01
Nonacid reflux	2.16 (1.26-3.72)	0.005	2.10 (1.21-3.64)	0.009
Acid reflux	1.06 (0.63-1.76)	0.83	0.92 (0.53-1.61)	0.77
Body-mass Index	1.01 (0.95-1.06)	0.85	1.02 (0.96-1.09)	0.43
Age at transplant	1.00 (0.98-1.02)	0.94	1.00 (0.97-1.02)	0.93
Male gender	0.85 (0.51-1.41)	0.53	0.75 (0.44-1.29)	0.30