Metronomic capecitabine inhibits liver transplant rejection in rats by triggering recipients’ T cell ferroptosis

Figure 4 Cytokine concentrations of peripheral blood and liver graft in transplanted rats. Use Luminex assay to detect the concentrations of interferon gamma (IFN-γ), tumor necrosis factor alpha (TNF-α), interleukin (IL)-2 and IL-12 in peripheral blood and graft. A and E: IFN-γ; B and F: TNF-α; C and G: IL-2; D and H: IL-12. Statistical analysis was done by unpaired Students t-test, n = 6. Data are shown as mean ± SD; ^aP < 0.05 vs the control group, ^bP < 0.01 vs the control group, ^cP < 0.001 vs the control group. CON: Untreated control groups, rats received 0.9% normal saline for 7 d; MET: Metronomic capecitabine (CAP)-treated groups, rats received metronomic CAP (100 mg/kg/d) treated for 7 d; IFN-γ: Interferon gamma; TNF-α: Tumor necrosis factor alpha; IL: Interleukin.