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©The Author(s) 2023.
World J Gastroenterol. May 28, 2023; 29(20): 3048-3065
Published online May 28, 2023. doi: 10.3748/wjg.v29.i20.3048
Published online May 28, 2023. doi: 10.3748/wjg.v29.i20.3048
Table 2 Main studies examining antineoplastic mechanisms of Hericium erinaceus against colorectal cancer
Ref. | H. erinaceus fraction employed | Colonic cancer model | Identified mechanism |
Kim et al[119], 2011 | Hot water/ microwave ethanol extraction extracts | CT-26 cancer cells graft in mice | NK cells activity ↑; macrophages activity ↑; angiogenesis ↓ |
Li et al[77], 2014 | Polysaccharides | HT-29 cancer cells graft in mice | - |
Lee et al[65], 2017 | Erinacine A | Cancer cells (HCT-116, DLD1) | PI3K/AKT/mTOR/; p70S6K pathway; ROS ↑ |
Sharif et al[120], 2018 | Ethanolic and methanolic extracts | Cancer cells (HT-29) | α-glucosidase activity ↑; anti-tyrosinase activity ↓ |
Liu et al[116], 2020 | Polysaccharides | Cancer cells (HCT-116) | CDK1 ↓; CDK2 ↓; Cyclin A2 ↓; MCM5 ↓ |
Hou et al[118], 2020 | Polysaccharides | Cancer cells (HCT-116, DLD1) | Clived caspases 3,9 ↑; ROS ↑; Bax ↑; Bcl-2 ↓ |
- Citation: Gravina AG, Pellegrino R, Auletta S, Palladino G, Brandimarte G, D’Onofrio R, Arboretto G, Imperio G, Ventura A, Cipullo M, Romano M, Federico A. Hericium erinaceus, a medicinal fungus with a centuries-old history: Evidence in gastrointestinal diseases. World J Gastroenterol 2023; 29(20): 3048-3065
- URL: https://www.wjgnet.com/1007-9327/full/v29/i20/3048.htm
- DOI: https://dx.doi.org/10.3748/wjg.v29.i20.3048