Current opinion on the regulation of small intestinal magnesium absorption

doi:10.3748/wjg.v29.i2.332

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jan 14, 2023; 29(2): 332-342
Published online Jan 14, 2023. doi: 10.3748/wjg.v29.i2.332

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Figure 4 Ovarian cancer G protein-coupled receptor 1 and acid-sensing ion-channel 1a modulate intestinal magnesium absorption. Activation of ovarian cancer G protein-coupled receptor 1 (OGR1) triggers the phospholipase C (PLC)–protein kinase C (PKC) signaling pathway to activate intestinal magnesium (Mg²⁺) absorption. Activation of acid-sensing ion-channel 1a (ASIC1a) activates intracellular calcium (Ca²⁺) signaling to induce mucosal bicarbonate secretion in a cystic fibrosis transmembrane conductance regulator (CFTR)-dependent mechanism. Secreted bicarbonate (HCO₃⁻) reduces free soluble Mg²⁺ and suppresses intestinal Mg²⁺ absorption. H: Hydrogen.

Citation: Chamniansawat S, Suksridechacin N, Thongon N. Current opinion on the regulation of small intestinal magnesium absorption. World J Gastroenterol 2023; 29(2): 332-342
URL: https://www.wjgnet.com/1007-9327/full/v29/i2/332.htm
DOI: https://dx.doi.org/10.3748/wjg.v29.i2.332