Acute-on-chronic liver failure: Controversies and consensus

Table 3 Defining organ/system failure using Chronic Liver Failure-Acute-on-Chronic Liver Failure Sequential Organ Failure Assessment scoring[12]

Organ system	Parameter	Score = 1	Score = 2	Score = 3
Liver	Serum bilirubin (mg/dL)	< 6	6-12	> 12
Kidney	Serum creatinine (mg/dL)	< 2	2.0-3.5	≥ 3.5 or renal replacement therapy
Brain	West-Haven grade	0	I-II	III-IV
Coagulation	INR	< 2.0	2.0-2.5	≥ 2.5
Circulation	MAP (mmHg)	≥ 70	< 70	Vasopressors
Respiratory	PaO2/FiO2	> 300	≤ 300 and > 200	≤ 200
	OR SpO2/FiO2	> 357	> 214 and ≤ 357	≤ 214

INR: International Normalized Ratio; MAP: Mean arterial pressure, mmHg millimeters of mercury; PaO2: Partial pressure of arterial oxygen; FiO2: Fraction of inspired oxygen; SpO2: Pulse oximetric saturation.