Acute-on-chronic liver failure: Controversies and consensus

Table 2 The European Association for the Study of the Liver and chronic Liver Failure Consortium grading of acute-on-chronic liver failure severity[12,25]

ACLF Grade	Criteria
No ACLF	No organ failure or; one organ failure (liver, coagulation, circulatory, respiratory) with serum creatinine < 1.5 mg/dL and no HE or single cerebral failure and serum creatinine < 1.5 mg/dL
Grade 1	Single kidney failure or single liver, coagulation, circulatory, or respiratory failure + serum creatinine 1.5-1.9 mg/dL and/or HE I-II or single cerebral failure (HE III-IV) + serum creatinine 1.5-1.9 mg/dL
Grade 2	2 organ failures
Grade 3	3 or more organ failures

HE: Hepatic encephalopathy; ACLF: Acute-on-chronic liver failure.