TATA-box-binding protein-associated factor 15 is a novel biomarker that promotes cell proliferation and migration in gastrointestinal stromal tumor

Figure 1 Differentially expressed proteins in gastrointestinal stromal tumor samples. A: Proteomic analysis identified the differentially expressed proteins in gastrointestinal stromal tumor (GIST) patients; B: Venn diagram showed the number of identified differentially expressed proteins in the subgroups of GIST; C and D: Western blotting identified that the expression level of TATA-box-binding protein-associated factor 15 (TAF15) was significantly increased in tumor tissues compared with matched normal tissues in all 18 GIST samples. P values were calculated using the Student’s t-test; E: Immunohistochemical analysis verified the expression of TAF15 using 161 GIST tumor tissues and 18 matched normal tissues (representative images are shown and red arrows indicate positive staining); F: Total immunostaining score of TAF15 protein in tumor tissues and matched normal tissues of GIST; G: Total immunostaining score of TAF15 proteins in the GIST subgroup. P values were calculated using the Student’s t-test or one-way analysis of variance. ^bP < 0.01. NS: No significance between groups; NIH-H: National Institutes of Health high risk; NIH-I: National Institutes of Health intermediate risk; NIH-L: National Institutes of Health low risk; NIH-VL: National Institutes of Health very low risk; IHC: Immunohistochemical; T: Tumor tissues; N: Normal tissues; FC: Fold change; TAF15: TATA-box-binding protein-associated factor 15.