Key elements determining the intestinal region-specific environment of enteric neurons in type 1 diabetes

Figure 2 Main elements determining the gut region-specific neuronal microenvironment. Enteric glia cells, interstitial cells of Cajal, intestinal vasculature and epithelium, enteroendocrine cells, intestinal microbiota and immune cells, balance of pro-oxidants and antioxidants and extracellular matrix molecules create and determine a strictly regional environment of enteric neurons in diabetes.