SARS-CoV-2 induced liver injury: Incidence, risk factors, impact on COVID-19 severity and prognosis in different population groups

Table 4 Most frequent liver-related histopathological findings in COVID-19 patients

Findings	Frequency (%)
Portal and sinusoidal microthrombosis	29.4–100
Hepatic/macrovesicular steatosis	50–75
Mild portal inflammation	13.2–66
Centrilobular necrosis	50
Mild acute hepatitis	50
Congestion/dilation of hepatic sinuses	34.7
Portal fibrosis	20.5
Kupffer cell hyperplasia	13.5
Lobular inflammation	11.6
Inflamed cells within the sinusoids (neutrophils, plasmatocytes and Kupffer)	N/A
Panacinar hepatitis, zone 3 necrosis	N/A

N/A: Not applicable; COVID-19: Coronavirus disease 2019.