Ferroptosis inhibition attenuates inflammatory response in mice with acute hypertriglyceridemic pancreatitis

Figure 4 The inhibition of ferroptosis attenuated P-407 + Caerulein-induced hypertriglyceridemic pancreatitis in mice (n = 4). A: Immunohistochemistry for Glutathione peroxidase 4 in the pancreas tissues of the P-407 + Caerulein (CAE) and P-407 + CAE + Ferrostatin-1 (Fer-1) groups; B: The malonaldehyde levels; C: The glutathione levels; D: Fe²⁺ levels in pancreases of P-407 + CAE and P-407 + CAE + Fer-1 groups; E: Hematoxylin–eosin (HE) staining and histological scores of the pancreas; F: HE staining and histological scores of the lung; G: HE staining and histological scores of the kidney; H: Serum tumor necrosis factor-α, interleukin (IL)-1β, and IL-6 levels of the P-407 + CAE and P-407 + CAE + Fer-1 groups. NOX: NADPH oxidase; ROS: Reactive oxygen species; CAE: Caerulein; MDA: Malonaldehyde; Fer-1: Ferrostatin-1; GSH: Glutathione; GPX4: Glutathione peroxidase 4; TNF: Tumor necrosis factor; IL: Interleukin.