Ferroptosis inhibition attenuates inflammatory response in mice with acute hypertriglyceridemic pancreatitis

Figure 1 P-407 and caerulein-induced hypertriglyceridemic pancreatitis in mice (n = 4). A: Serum total cholesterol and triglyceride levels; B: Serum amylase; C: Alanine aminotransferase and Alanine aminotransferase levels; D: Homeostasis model assessment insulin resistance index levels in mice exposed to P-407 and caerulein (CAE); E: Hematoxylin–eosin (HE) staining and histological scores of the pancreas; F: HE staining and histological scores of the lung; G: HE staining and histological scores of the kidney; H: Serum Tumor necrosis factor-α, interleukin (IL)-1β, and IL-6 levels after P-407 and CAE exposure. AST: Aspartate transaminase; ALT: Alanine aminotransferase; HOMA-IR: Homeostasis model assessment insulin resistance index; HE: Hematoxylin–eosin; CAE: Caerulein; AMY: Amylase; TNF: Tumor necrosis factor; IL: Interleukin; NS: Not significant.