Anti-inflammatory effect and antihepatoma mechanism of carrimycin

Figure 8 PI3K-Akt signaling pathway regulation. This plot shows the genes that are upregulated or downregulated (red) and downregulated (green) by carrimycin in the PI3K-Akt pathway. Grb2: Growth factor receptor bound protein 2; RTK: Receptor tyrosine kinase; GF: Growth factor; IRS1: Insulin receptor substrate 1; TLR: Toll-like reCEPT; BCR: Breakpoint cluster region; ECM: Extracellular matrix; ITGA: Integrin subunit alpha; FAK: Focal Adhesion Kinase; JAK: Janus kinase; GPCR: G protein-coupled receptor; AMP: Adenosine Mono Phosphate; LKB1: Liver kinase B1; REDD1: regulated in development and DNA damage responses-1; AMPK: AMP-activated protein kinase; TSC: tuberous sclerosis; Rheb: Right Hand Equipment Bay; PDK1: Pyruvate dehydrogenase kinase, isozyme 1; CTMP: Carboxy terminal modulator protein; PP2A: Protein phosphatase 2A regulatory subunit; PIP: Phosphoinositide-binding protein; PTEN: Phosphatase and tensin homolog; PHLPP: PH domain leucine-rich repeat protein phosphatase; CDC: Cell division cycle gene; HSP: Heat shock protein; RAF: Rheumatoid Arthritis Factor; MEK: Mitogen-activated protein; ERK: Extracellular regulated protein kinases; ENOS: Endothelial nitric oxide synthase; BRCA: Breast cancer susceptibility genes; PEPCK: Phosphoenolpyruvate carboxykinase; FOXO: Forkhead Box O; MDM2: Murine double minute 2; CCND1: Recombinant Cyclin D1; RBL2: Retinoblastoma-like 2; MDM2: Murine double minute 2; mTOR: Mammalian target of rapamycin (a protein).