Effectiveness of Helicobacter pylori eradication in the treatment of early-stage gastric mucosa-associated lymphoid tissue lymphoma: An up-to-date meta-analysis

Table 1 Characteristics of the included studies

Ref.	Country	Design	Study period	Study population
				Early-stage gastric MALT lymphoma, n	Lugano stage	Median follow-up in mo	H. pylori-positive early-stage GML, n	Diagnosis of H. pylori infection
Yang et al[18], 2021	China	Retrospective	2003-2015	70	70	30	52	UBT; HE
Schmelz et al[19], 2019	Germany	Prospective	2001-2010	109	109	12	99	HE
Sugizaki et al[20], 2018	Japan	Prospective	2010-2016	97	97	37.4	97	HE; HpC; RUT; UBT; HpSA; S
Song et al[21], 2018	China	Prospective	2000-2013	122	122	38	47	RUT; HE; UBT
Li et al[22], 2016	China	Retrospective	2001-2013	75	75	62.9	69	HE; UBT
Kim et al[24], 2016	Korea	Retrospective	2001-2014	49	49	51	40	HE; UBT; RUT
Moleiro et al[23], 2016	Korea	Retrospective	2005-2014	103	103	50.5	82	RUT; UBT; HE
Park et al[25], 2016	Portugal	Retrospective	1993-2013	103	103	105	87	HE; HpC; S; UBT
Grgov et al[26], 2015	Serbia	Prospective	2002-2012	20	20	NR	20	RUT; HE
Nonaka et al[27], 2014	Japan	Retrospective	2007-2012	16	16	NR	12	HE; S; UBT
Lima et al[28], 2014	Brazil	Prospective	2009-2010	8	8	24	7	RUT; HE; UBT
Wündisch et al[29], 2012	Germany	Prospective	1993-1999	120	120	122	120	HE
Choi et al[30], 2011	Korea	Retrospective	2003-2010	35	35	21.5	26	HE; RUT; UBT
Ono et al[31], 2011	Japan	Retrospective	2003-2009	21	21	1	13	RUT; UBT; HpC; HE; S
Andriani et al[32], 2009	Italy	Retrospective	1993-2006	60	60	65	60	HE
Sumida et al[33], 2009	Japan	Prospective	1997-2007	66	66	40	57	HE; S; UBT
Stathis et al[34], 2009	Switzerland	Retrospective	1990-2006	105	105	75.6	85	HE; S; UBT
Terai et al[35], 2008	Japan	Prospective	1995-2006	74	74	46	70	RUT; HE; S; UBT
Fischbach et al[36], 2007	Germany	Retrospective	NR	108	108	42.2	108	HE; UBT
Kim et al[37], 2007	Korea	Prospective	1996-2006	99	99	41	99	HE; RUT
El-Zahabi et al[38], 2007	Lebanon	Retrospective	1999-2005	22	22	12	19	HE; S
Hong et al[39], 2006	Korea	Prospective	1996-2003	90	90	45	90	HE; RUT; UBT
Wündisch et al[40], 2006	Germany	Retrospective	1993-2003	196	196	27	196	HE
Akamatsu et al[41], 2006	Japan	Prospective	1993-2006	55	55	37.3	38	HpC; HE
Wündisch et al[42], 2005	Germany	Prospective	NR	120	120	75	120	HE
Montalban et al[43], 2005	Spain	Prospective	1993-2002	24	24	64	24	HE; UBT
Chen et al[44], 2005	Taiwan	Prospective	1996-1999	34	34	70	31	HE; RUT; S
Taji et al[45], 2005	Japan	Prospective	1995-2001	13	13	32.5	12	HE; HpC; S; UBT; RUT
Takenaka et al[46], 2004	Japan	Prospective	1995-2002	33	33	5	33	HpC; RUT
Fischbach et al[47], 2004	Germany	Prospective	NR	90	90	44.6	80	RUT; HE; UBT
Sheu et al[48], 2003	Taiwan	Prospective	NR	15	15	NR	15	RUT; HE
Caletti et al[49], 2002	Italy	Prospective	1997-1999	51	51	24	51	HE; RUT; S
Nakamura et al[50], 2002	Japan	Prospective	1994-2001	21	21	14.5	17	HpC; S
Liu et al[51], 2002	France; Netherlands; Italy; Germany; England	Retrospective	NR	111	111	NR	111	HE; HpC
Bertoni et al[52], 2002	England; Italy; Switzerland	Prospective	NR	62	62	24	62	HE; S
Ohashi et al[53], 2002	Japan	Prospective	NR	13	13	NR	13	RUT; HE; HpC
Kim et al[54], 2002	Korea	Prospective	NR	20	20	18.3	20	RUT; HE
Matsushima et al[55], 2002	Japan	Prospective	1995-1997	14	14	27.5	14	RUT; HE; HpC; UBT
Kanda et al[56], 2001	Japan	Prospective	1994-1999	13	13	7	13	HE
Raderer et al[57], 2001	Austria	Retrospective	1997-1999	22	22	25	22	HE
Nakamura et al[58], 2001	Japan	Prospective	1994-1998	41	41	20.5	41	HpC; S; HE
Ruskoné-Fourmestraux et al[59], 2001	France	Prospective	1995-1998	44	44	35	34	HE; HpC; S; PCR
Thiede et al[60], 2001	Germany	Prospective	NR	97	97	20.8	97	NR
de Jong et al[61], 2001	Netherlands	Prospective	NR	23	23	37	23	HE; HpC
Urakami et al[62], 2000	Japan	Prospective	NR	47	47	20	47	RUT; HE; HpC
Papa et al[63], 2000	Italy	Prospective	1995-1999	7	7	48	7	HE; UBT
Yamashita et al[64], 2000	Japan	Prospective	NR	21	21	NR	21	HE; RUT; HpC
Ohashi et al[65], 2000	Japan	Prospective	NR	11	11	NR	11	RUT; HE; HpC
Nakamura et al[66], 2000	Japan	Prospective	1993-1998	30	30	NR	26	HpC
Savio et al[67], 2000	Italy	Prospective	1991-1997	76	76	NR	76	HE
Weston et al[68], 1999	United States	Prospective	NR	68	68	NR	65	HE
Steinbach et al[69], 1999	United States	Prospective	NR	34	34	NR	28	HE; RUT; S
Nobre-Leitão et al[70], 1998	Portugal	Prospective	NR	17	17	12	17	HE; HpC
Thiede et al[71], 1997	Germany	Prospective	NR	84	84	NR	84	NR
Sackmann et al[72], 1997	Germany	Prospective	NR	22	22	10	22	HE; HpC
Neubauer et al[73], 1997	Germany	Prospective	NR	50	50	24	50	HE
Pinotti et al[74], 1997	Italy; Switzerland	Prospective	1986-1995	86	86	23.3	45	HE; S
Savio et al[75], 1996	Italy; England	Prospective	1991-1993	13	13	NR	13	HE
Bayerdörffer et al[76], 1995	Germany	Prospective	NR	33	33	12.5	33	HE
Roggero et al[77], 1995	Switzerland; Italy	Prospective	NR	26	26	12	26	HE
Wotherspoon et al[78], 1993	England; Italy	Prospective	NR	6	6	NR	6	HE

CR: Complete remission rate; GML: Gastric mucosa-associated lymphoid tissue lymphoma; H. pylori: Helicobacter pylori; HE: Histologic examination; HpC: Helicobacter pylori culture; HpSA: Helicobacter pylori stool antigen; MALT: Mucosa-associated lymphoid tissue; NR: Not reported; PPI: Proton pump inhibitor; RUT: Rapid urease test; S: Serology; UBT: 13C- or 14C-urea breath test.