Acoustic radiation force impulse predicts long-term outcomes in a large-scale cohort: High liver cancer, low comorbidity in hepatitis B virus

Table 3 Logistic regression for hepatocellular carcinoma diagnosed before enrollment

	Univariate analysis	Multivariate analysis		95%CI
	P value	P value	Hazard ratio	Lower	Upper
Male	< 0.001	0.000	3.399	2.150	5.373
Etiology	< 0.001	0.000	-	-	-
HBV		0.000	4.009	2.219	7.241
HCV		0.169	1.644	0.810	3.335
Age, yr	< 0.001	0.000	1.047	1.029	1.066
ALT	0.243	0.001	0.993	0.989	0.997
AST	0.010	0.000	1.012	1.007	1.017
Bilirubin	0.170	0.729	0.980	0.875	1.098
Platelet	0.138	0.035	1.003	1.000	1.005
Spleen index	0.060	0.811	1.001	0.990	1.013
BMI	0.015	0.076	0.956	0.910	1.005
ARFI	< 0.001	0.010	1.556	1.110	2.181
Interferon therapy	0.011	0.012
Pre-enrollment		0.618	1.204	0.581	2.496
Post-enrollment		0.004	0.211	0.073	0.617
Oral anti-virus agents	0.041	0.181
Pre-enrollment		0.168	1.721	0.795	3.728
Post-enrollment		0.156	0.667	0.381	1.167
Pre- and post-enrollment		0.527	1.534	0.408	5.773
Hypertension	< 0.001	0.000	2.551	1.702	3.824
Diabetes mellitus	< 0.001	0.031	1.618	1.044	2.508
Dyslipidemia	< 0.001	0.000	0.358	0.207	0.620
Ischemic stroke	0.341	0.884	1.097	0.317	3.794

1481/1962 (75.5%) with complete data; cases (hepatocellular carcinoma), n = 189. HBV: Hepatitis B; HCV: Hepatitis C; ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; BMI: Body mass index; ARFI: Acoustic radiation force impulse.