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©The Author(s) 2023.
World J Gastroenterol. Apr 14, 2023; 29(14): 2078-2100
Published online Apr 14, 2023. doi: 10.3748/wjg.v29.i14.2078
Published online Apr 14, 2023. doi: 10.3748/wjg.v29.i14.2078
Table 5 Summary of preclinical studies of synbiotics
Ref. | Model | Probiotics | Prebiotics | Dose | Parameters analyzed | Conclusion |
Xue et al[80], 2023 | DSS-induced colitis in mice | Lactobacillus plantarum LP90 | Soluble dietary fiber obtained from Lentinula edodes by products | 1 × 109 CFU/kg | DAI, histological studies, IL-10, IL-17, IgA levels, TNF-α | Alleviated colitis |
Ivanovska et al[81], 2017 | DSS-induced colitis in C57BL/6J mice | Bifidobacterium infantis and Bifodobacterium longum | Equal parts FOS, GOS and XOS | 0.5 × 109 CFU Probiotics and 2.5 g of prebiotics for 1 mo | Gut microbiome, cecal and fecal SCFAs | Increased the diversity of the microbiome and be associated with more SCFAs, and less gut inflammation |
Seong et al[82], 2020 | Chronic restraint stress in male Wistar rats | L. paracasei | Opuntia humifusa extract (mucilage + pectin) | L. paracasei (1 × 1010 CFU/g) & (10.0/30.0 mg%, w/w) of Opuntia humifusa extract once daily for 4 wk | Fecal microbial analysis, serum corticosterone levels, TNF-α levels in the colon tissue | Effective (greater abundance of L. paracasei in fecal microbial analysis, lower serum corticosterone levels, lower TNF-α levels in the colon tissue |
dos Santos Cruz et al[83], 2020 | IL 10- knockout mice | VSL#3 | Yacon (6% FOS + inulin) | VSL#3 (109 CFU/d) + PBY (6% FOS and inulin) for 13 wk | Manifestations of colitis, colon histology, expression of antioxidant enzymes, production of organic acids, and intestinal microbiota | Preservation of intestinal architecture, improve intestinal integrity, increased expression of antioxidant enzymes and concentration of organic acids |
Wang et al[84], 2019 | DSS-induced colitis in C57BL/6J mice | Lactobacillus acidophilus, L. Rhamnosus, and Bifidobacterium lactis | Inulin | Probiotics: 1.0 × 109 CFU per day per mice, and prebiotic 5 × 108 CFU/d | Pathologic scores, mucosal flora | Increased the proportion of helpful bacteria and regulated the balance of intestinal microbiota, reduced the degree of inflammation in acute colitis mice |
Son et al[85], 2019 | DSS-induced colitis in female BALB/c mice | LGG | Tagatose | 109 CFU/mL of LGG and 25 mg of tagatose once in 2 d for 3 wk | Body weight, food intake, rectal bleeding, stool conditions, blood in stool, expression of proinflammatory cytokines | Effective (gut microbiota composition recovered from the dysbiosis caused by DSS treatment) |
Ivanovska et al[81], 2017 | TNBS-induced colitis in Wistar rats | L. Casey 01 | Oligofructose-enriched inulin | 1 mL containing non-encapsulated probiotic/prebiotics once daily for 2 wk | Assessment of colonic damage, inflammation scoring, MPO and microbiological studies | Effective |
- Citation: Roy S, Dhaneshwar S. Role of prebiotics, probiotics, and synbiotics in management of inflammatory bowel disease: Current perspectives. World J Gastroenterol 2023; 29(14): 2078-2100
- URL: https://www.wjgnet.com/1007-9327/full/v29/i14/2078.htm
- DOI: https://dx.doi.org/10.3748/wjg.v29.i14.2078