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©The Author(s) 2023.
World J Gastroenterol. Apr 14, 2023; 29(14): 2078-2100
Published online Apr 14, 2023. doi: 10.3748/wjg.v29.i14.2078
Published online Apr 14, 2023. doi: 10.3748/wjg.v29.i14.2078
Table 3 Summary of preclinical studies of prebiotics
Ref. | Model | Type of treatment | Composition | Dose | Parameters analyzed | Conclusion |
Cui et al[57], 2021 | DSS-induced colitis in C57BL/6J mice | Polysaccharide from Scutellaria baicalensis Georgi | Mannose, ribose, rhamnose, glucuronic acid, glucose, xylose, arabinose, fucose | 50 and 200 mg/kg once daily for 10 d | Body weight, loose stools, morbidity, hematochezia, and the DAI | Effective (attenuated body weight loss, reduced DAI, ameliorated colonic pathological damage, and decreased MPO activity) |
Tolonen et al[58], 2022 | DSS-induced colitis in male C57Bl/6 mice | Synthetic glycans | FOS, GOS, XOS, pullulan, and lactulose | 1% (v/v) glycans (days 7-14) | Weight loss, scores of diarrhea, endoscopy, and colonic histology | Synthetic glycans increase survival, reduce weight loss, and improve clinical scores in mouse models of colitis |
Qian et al[59], 2022 | DSS-induced colitis in male C57Bl/6 mice | GOS, FOS along with FMT | FMT alone or combined with various ratios of GOS, and FOS | - | DAI scores, histology, protein or mRNA expression levels of FFAR3 and ZO-1, a tight junction protein | Treatment with FMT plus a prebiotic blend restores thestructure of the intestinal flora and increased the levels of acetic acid, butyric acid, FFAR3, and ZO-1 |
Liu et al[60], 2016 | DSS-induced colitis in male C57BL/6 mice | Alpha D-glucan from marine fungus Phoma herbarum YS4108 | Glucopyranose | 40 mg/kg/d once daily for 1 wk | DAI scores, histology immunohistochemistry analysis, evaluation of SOD and MDA activities, and determinations of inflammatory cytokines | Effective (significantly increased butyrate, isovaleric acid levels, and prominent alterations on specific microbiota) |
He et al[61], 2020 | DSS-induced colitis in male C57BL/6 mice | Stachyose | Stachyose | 1.5 g/kg/d for 28 d | Inflammatory cytokines including IL-6, IL-10, IL-17a, and TNF-α | Increased beneficial microbiota and bacterial diversity to alleviate acute colitis in mice |
Kanwal et al[62], 2019 | Dictyophora indusiate polysaccharide | Glucose 59.84%, mannose 23.55%, and galactose 12.95% | Low dose 10 mg/kg and (high dose 33 mg/kg once daily for 2 wk | Assessment of DAI, histological, analysis of goblet cells and mucus layer thickness, cytokines | Effective | |
Li et al[63], 2020 | Male C57BL/6 mice | FMG or dealcoholized muscadine wine | FMG: Fructose 34.7% glucose 31%, sucrose 9.9%. DMW: Fructose, sucrose, and glucose not detected | FMG (7%, w/w) or DMW (5.5%, v/ w) for 3 wk | Bodyweight, stool consistency and bleeding, DAI, short-chain fatty acids in feces, and Mucin 2 and IgA in feces | Effective (reduced dysbiosis in the colon) |
K-da et al[64], 2020 | Male C57BL/6 mice | GFO | Monosaccharide composition in the GFO was D-galactose | 100, 500, or 1000 mg/kg once daily for 2 wk | GI transit time, ex vivo propulsive motility, in vitro colonic smooth muscle contractility, the composition of colonic microbiota, and production of SCFAs | Effective (prevented and attenuated colitis symptoms and GI dysmotility, reducing populations of harmful bacteria and increasing SCFAs) |
- Citation: Roy S, Dhaneshwar S. Role of prebiotics, probiotics, and synbiotics in management of inflammatory bowel disease: Current perspectives. World J Gastroenterol 2023; 29(14): 2078-2100
- URL: https://www.wjgnet.com/1007-9327/full/v29/i14/2078.htm
- DOI: https://dx.doi.org/10.3748/wjg.v29.i14.2078