Antihepatoma peptide, scolopentide, derived from the centipede scolopendra subspinipes mutilans

Figure 4 Cytotoxicity of synthetic scolopentide to L02 cells and HepG2 cells. A: The CCK8 assay showed that cytotoxicity to L02 cells was significantly lower than that to HepG2 cells after treatment with synthetic scolopentide for 12 h (100 μg/mL, 150 μg/mL, and 200 μg/mL); B: Morphological changes in HepG2 and L02 cells under a light microscope after treatment with synthetic scolopentide for 12 h (× 100). Compared to cells in the vehicle group (0 μg/mL), most HepG2 cells in the scolopentide group (100 μg/mL) died, while some L02 cells survived. ^dP < 0.0001.