Linked color imaging vs Lugol chromoendoscopy for esophageal squamous cell cancer and precancerous lesion screening: A noninferiority study

Table 3 Clinicopathological features of neoplastic lesions (non-inflammation) detected by linked color imaging and Lugol chromoendoscopy, n (%)

Item		Detected by LCI, n = 36 patients/38 lesions	Detected by LCE, n = 39 patients/41 lesions	P value
Lesion location				0.969
Upper		3 (7.9)	3 (7.3)
Middle		11 (28.9)	11 (26.8)
Lower		24 (63.2)	27 (65.9)
Morphologic type				0.902
I		1 (2.6)	1 (2.4)
IIa		9 (23.7)	8 (19.5)
IIb		18 (47.4)	24 (58.5)
IIc		9 (23.7)	7 (17.1)
III		1 (2.6)	1 (2.4)
Size in mm				0.814
≤ 10		14 (36.8)	18 (43.9)
10-20		3 (7.9)	3 (7.3)
> 20		21 (55.3)	20 (48.8)
Pathology				0.998
LGIN		18 (47.4)	21 (51.2)
HGIN		3 (7.9)	3 (7.3)
ESCC	EP/LPM	3 (7.9)	3 (7.3)
	MM/SM1	1 (2.6)	1 (2.4)
	≥ SM2	13 (34.2)	13 (31.7)
Procedure time (s), median (IQR)		42 (34, 50)	160 (130, 189)	< 0.0011

¹P value < 0.01.

EP: Epithelial; ESCC: Esophageal squamous cell carcinoma; HGIN: High-grade intraepithelial neoplasia; IQR: Interquartile range; LCE: Lugol chromoendoscopy; LCI: Linked color imaging; LGIN: Low-grade intraepithelial neoplasia; LPM: Lamina propria mucosa; MM: Muscularis mucosa; SM1: Submucosa invading ≤ 200 μm below the inferior margin of the muscularis mucosa; SM2: Submucosa invading > 200 μm below the inferior margin of the muscularis mucosa.