In vivo recognition of bioactive substances of Polygonum multiflorum for protecting mitochondria against metabolic dysfunction-associated fatty liver disease

Figure 8 Effects of Polygonum multiflorum-derived monomer group in liver mitochondria on serum biochemical parameters of high-fat diet-fed mice. Mice were administered saline, Polygonum multiflorum-derived monomer groups (30 and 90 mg/kg/d), or resveratrol (18 mg/kg/d). After 3 mo of high-fat diet feeding, mice were sacrificed, and serum was collected. A: Serum levels of total cholesterol were determined using a commercial kit; B: Serum levels of aspartate transaminase were determined using a commercial kit; C: Serum levels of low-density lipoprotein cholesterol were determined using a commercial kit. Values represent the mean ± SD from six animals. ^aP < 0.05, ^bP < 0.01, ^cP < 0.001 vs model group. AST: Aspartate transaminase; HMG: High-dose Polygonum multiflorum-derived monomer group; LDL-C: Low-density lipoprotein cholesterol; LMG: Low-dose Polygonum multiflorum-derived monomer group; MOD: Model; NC: Normal control; RES: Resveratrol; TC: Total cholesterol.