Review
Copyright ©The Author(s) 2023.
World J Gastroenterol. Jan 7, 2023; 29(1): 43-60
Published online Jan 7, 2023. doi: 10.3748/wjg.v29.i1.43
Table 1 Summary of the studies that evaluated radiomics to preoperatively predict hepatocellular cholangiocarcinoma histology
Ref.
Country
n
Imaging modality
Endpoint
Segmentation
ROI/VOI
No. of readers
Main results
Validation
Wang et al[92], 2022China196MRIcHCC-CC vs HCCManual, intratumoralROI1AUC (delayed phase MRI): 0.91None
Liu et al[24], 2021Canada85MRI and CTcHCC-CC vs HCC vs CCManual, intratumoralROI2AUC (MRI): 0.77-0.81. AUC (CT): 0.71-0.81Cross-validation
Lewis et al[25], 2019United States63MRIcHCC-CC vs HCC vs CCManual, intratumoralVOI2AUC (LI-RADS and male gender): 0.90None
Nie et al[27], 2020China156CTHCC vs FNHManual, intratumoralROI2AUC (radiomics): 0.96 training, 0.87 validation. AUC (radiomics + clinical factors): 0.98 training, 0.92 validationNone
Wu et al[28], 2019China369MRIHCC vs hemangiomaManual, intratumoralROI2AUC: 0.86 training, 0.89 testingNone
Mokrane et al[29], 2020United States178CTHCC diagnosisManual, intratumoralVOI2AUC: 0.70 training, 0.66 validationExternal
Brancato et al[34], 2022Italy38MRITumor gradeManual, intratumoralVOI1AUC: 0.89None
Gao et al[93], 2018ChinaTraining: 125. Validation: 45MRITumor gradeManual, intratumoralN/AN/AAUC: 0.83 training, 0.74 validationNone
Wu et al[30], 2019ChinaTraining: 125. Validation: 45MRITumor gradeManual, intratumoralROI1AUC: 0.83 training, 0.74 validationInternal
Zhou et al[94], 2017China46MRITumor gradeManual, intratumoralROI1AUC: 0.83-0.92None
Mao et al[31], 2022ChinaTraining: 85. Validation: 37MRITumor gradeManual, intratumoralROI2AUC: 0.97 training, 0.94 validationInternal
Chen et al[33], 2021ChinaTraining: 112. Validation: 49CTTumor gradeManual, intratumoralVOI2AUC: 0.90 training, 0.94 validationInternal
Yang et al[95], 2019ChinaTraining: 146. Validation: 62Gadoxetic acid-enhanced MRIMVIManual, intratumoralROI2 (consensus)AUC: 0.94 training, 0.86 validationInternal
Xu et al[39], 2019China495CTMVISemi-automatic, intratumoral and peritumoralVOI3AUC: 0.91 training, 0.89 validationInternal
Feng et al[40], 2019China160Gadoxetic acid-enhanced MRIMVIManual, intratumoral and peritumoralVOI3AUC: 0.85 training, 0.83 validationInternal
Zheng et al[41], 2017United States120CTMVISemi-automaticROI1AUC: 0.80None
Bakr et al[96], 2017United States28CTMVIManual, intratumoralROI4AUC: 0.76None
Ma et al[97], 2019China157CTMVIManual, intratumoralVOI1AUC (portal venous phase CT): 0.79Cross-validation