Impact of Helicobacter pylori virulence markers on clinical outcomes in adult populations

Table 4 Associations between virulence factors, patient ethnicity, and disease severity, n (%)

	Disease severity					P value
	Unremarkable, n = 18	Mild, n = 50	Moderate, n = 37	Severe, n = 3	Total, n = 108
Ethnicity						0.002
Arab	5 (27.8)	21 (42.0)	28 (75.7)	2 (66.7)	56 (51.9)
Jewish	13 (72.2)	29 (58.0)	9 (24.3)	1 (33.3)	52 (48.1)
Urease activity
t1	0.32 (0.05)	0.29 (0.06)	0.29 (0.07)	0.30 (0.06)	0.30 (0.06)	0.273
t5	0.32 (0.05)	0.30 (0.05)	0.29 (0.07)	0.34 (0.02)	0.30 (0.06)	0.174
t10	0.32 (0.05)	0.30 (0.06)	0.30 (0.06)	0.35 (0.04)	0.30 (0.06)	0.171
t15	0.33 (0.04)	0.31 (0.05)	0.31 (0.06)	0.36 (0.03)	0.31 (0.05)	0.245
CagA gene						0.534
CagA-	13 (72.2)	41 (82.0)	27 (73.0)	3 (100)	84 (77.8)
CagA+	5 (27.8)	9 (18.0)	10 (27.0)	0 (0)	24 (22.2)
VacA s allele						0.651
VacA s1	5 (27.8)	22 (44.0)	16 (43.2)	1 (33.3)	44 (40.7)
VacA s2	13 (72.2)	28 (56.0)	21 (56.8)	2 (66.7)	64 (59.3)
VacA m Allele						0.652
VacA m1	3 (16.7)	14 (28.0)	7 (18.9)	1 (33.3)	25 (23.1)
VacA m2	15 (83.3)	36 (72.0)	30 (81.1)	2 (66.7)	83 (76.9)
Genotype						0.926
CagA+/s1m1	0 (0)	3 (6.0)	4 (10.8)	0 (0)	7 (6.5)
CagA+/s1m2	1 (5.6)	2 (4.0)	3 (8.1)	0 (0)	6 (5.6)
CagA+/s2m2	2 (11.1)	2 (4.0)	2 (5.4)	0 (0)	6 (5.6)
CagA+/s2m1	1 (5.6)	1 (2.0)	1 (2.7)	0 (0)	3 (2.8)
CagA-/s1m1	2 (11.1)	7 (14.0)	2 (5.4)	1 (33.3)	12 (11.1)
CagA-/s1m2	2 (11.1)	11 (22.0)	7 (18.9)	0 (0)	20 (18.5)
CagA-/s2m2	10 (55.6)	22 (44.0)	18 (48.6)	2 (66.7)	52 (48.1)
CagA-/s2m1	0 (0)	2 (4.0)	0 (0)	0 (0)	2 (1.9)

VacA: Vacuolating cytotoxin A; CagA: Cytotoxin-associated gene A.