Emerging roles of non-coding RNAs in colorectal cancer oxaliplatin resistance and liquid biopsy potential

Table 1 Dysregulation of microRNAs and oxaliplatin resistance in colorectal cancer

MiRNAs	Expression1	Targets and pathways	Ref.
miR-135b-5p	↑	MUL1/ULK1	[49]
miR-454-3p	↑	PTEN	[50]
miR-19a	↑	PTEN/PI3K/AKT	[51]
miR-543	↑	PTEN/Akt/mTOR	[52]
miR-107	↑	CAB39/AMPK/mTOR	[53]
miR-503-5p	↑	PUMA	[54]
miR-744	↑	BIN1	[55]
miR-5000-3p	↑	USP49	[56]
miR-146b-5p	↑	WBSCR22	[57]
miR-19b-3p	↑	SMAD4	[58]
miR-1278	↓	-	[59]
miR-506	↓	Wnt/β-catenin	[60]
miR-200b-3p	↓	TUBB3	[61]
miR-122	↓	XIAP	[62]
miR-193a-5p	↓	CXCR4	[63]
miR-483-3p	↓	FAM171B	[64]
miR-325	↓	HSPA12B/PI3K/AKT/Bcl-2	[65]
miR-195-5p	↓	-	[66]
miR-497-5p	↓	-
miR-34a	↓	TGF-β/Smad4	[68]
miR-27b-3p	↓	-	[69]

¹Aberrant expression of miRNAs either up-regulated (↑) or down-regulated (↓) in CRC oxaliplatin resistance.

MiRNAs: MicroRNAs.