Postoperative morbidity adversely impacts oncological prognosis after curative resection for hilar cholangiocarcinoma

Table 6 Univariable and multivariable Cox regression analyses of risk factors associated with recurrence-free survival following curative resection for hilar cholangiocarcinoma

Variables	Univariable analyses		Multivariable analyses1
	P value	HR (95%CI)	P value	HR (95%CI)
Age > 60 yr	0.330	1.201 (0.850-1.696)
Male sex	0.998	1.002 (0.793-1.136)
ASA score > 2	0.457	1.210 (0.732-1.997)
Obesity	0.911	0.973 (0.604-1.568)
Diabetes mellitus	0.035	1.654 (1.036-2.264)	0.177	1.403 (0.858-2.295)
Cirrhosis	0.247	1.260 (0.852-1.863)
Preoperative CA19-9 > 150 U/L	0.002	1.617 (1.193-2.192)	0.012	1.487 (1.092-2.024)
Maximum tumor size > 3 cm	0.002	1.695 (1.223-2.351)	0.002	1.665 (1.198-2.314)
Macrovascular invasion	0.008	1.534 (1.120-2.100)	0.011	1.514 (1.101-2.081)
Microvascular invasion	0.009	1.524 (1.118-2.088)	0.121	1.295 (0.934-1.794)
Peripheral nerve invasion	0.683	1.068 (0.780-1.462)
Poor tumor differentiation	0.007	1.547 (1.124-2.129)	0.006	1.575 (1.141-2.173)
Intraoperative blood transfusion	0.251	1.208 (0.875-1.668)
Intraoperative blood loss > 500 mL	0.819	1.043 (0.729-1.490)
Major hepatectomy	0.978	0.995 (0.718-1.379)
LN metastasis	0.010	1.573 (1.114-2.220)	0.017	1.528 (1.080-2.157)
Bismuth type, III-IV	0.788	1.042 (0.771-1.410)
Preoperative drainage	0.517	0.895 (0.640-1.252)
Postoperative morbidity	0.003	1.169 (1.180-2.220)	0.008	1.535 (1.117-2.108)

¹Those variables found significant at P < 0.100 in univariable analyses were entered into multivariable Cox regression analyses.

ASA: American Society of Anesthesiologists; CA19-9: Carbohydrate antigen 19-9; CI: Confidence interval; HR: Hazard ratio; LN: Lymph node.