Sex-based differences in histology, staging, and prognosis among 2983 gastric cancer surgery patients

Table 2 Univariate and multivariate analyses for gastric cancer related morbidity

Variable	Univariate analysis	P value	Multivariate analysis	P value
Sex
Male	Ref	0.169	Ref	0.672
Female	1.22 (0.92-1.61)		1.06 (0.80-1.42)
Age
< 60	Ref	0.001a	Ref	< 0.001a
≥ 60	1.64 (1.23-2.18)		2.02 (1.50-2.73)
Drinking history
No	Ref	0.996
Yes	1.00 (0.76-1.32)
Smoking history
No	Ref	0.283
Yes	1.16 (0.88-1.53)
Family history
No	Ref	0.189	Ref	0.165
Yes	0.77 (0.51-1.14)		0.75 (0.51-1.12)
Tumor location
Upper	Ref	0.003a	Ref	< 0.001a
Middle	1.65 (0.41-6.71)		1.40 (0.34-5.71)
Lower	2.61 (0.65-10.54)		2.63 (0.65-10.64)
Atrophic gastritis
No	Ref	0.871
Yes	0.97 (0.71-1.34)
Intestinal metaplasia
No	Ref	0.412
Yes	0.89 (0.67-1.18)
Histologic type (Lauren classification)
Intestinal	Ref	< 0.001a	Ref	< 0.001a
Diffuse	2.16 (1.62-2.89)		3.07 (2.25-4.19)
Mixed	2.25 (1.29-3.92)		2.50 (1.43-4.35)
P53
Negative	Ref	0.651
Positive	1.07 (0.80-1.42)

^aP < 0.05 indicates statistical significance.

P < 0.2 were used for multivariable analyses.