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World J Gastroenterol. Feb 28, 2022; 28(8): 794-810
Published online Feb 28, 2022. doi: 10.3748/wjg.v28.i8.794
Table 2 Classification of mixed neuroendocrine-nonneuroendocrine neoplasms depending on the grade of malignancy[15]
Grade of MiNEN
Nonneuroendocrine component
Endocrine component
High-grade AdenocarcinomaPDNEC, NET G31
Squamous cell carcinoma
Cholangiocarcinoma
Ductal and acinar cell carcinoma
Ductal adenocarcinoma
High-gradeAcinar cell carcinomaNET, G1 or G21
Ductal adenocarcinoma
Acinar cell carcinoma
Intermediate gradeAdenocarcinomaNET, G1 or G21
Low-grade2Adenoma NET, G1 or G2