Mixed neuroendocrine–nonneuroendocrine neoplasms of the gastrointestinal system: An update

doi:10.3748/wjg.v28.i8.794

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Feb 28, 2022 (publication date) through Oct 2, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Feb 28, 2022; 28(8): 794-810
Published online Feb 28, 2022. doi: 10.3748/wjg.v28.i8.794

Table 2 Classification of mixed neuroendocrine-nonneuroendocrine neoplasms depending on the grade of malignancy[15]

Grade of MiNEN	Nonneuroendocrine component	Endocrine component
High-grade	Adenocarcinoma	PDNEC, NET G3¹
	Squamous cell carcinoma
	Cholangiocarcinoma
	Ductal and acinar cell carcinoma
	Ductal adenocarcinoma
High-grade	Acinar cell carcinoma	NET, G1 or G2¹
	Ductal adenocarcinoma
	Acinar cell carcinoma
Intermediate grade	Adenocarcinoma	NET, G1 or G2¹
Low-grade²	Adenoma	NET, G1 or G2

¹Grading should be performed according to the latest WHO classification.

²Those tumors are not included in the mixed neuroendocrine-nonneuroendocrine neoplasms category.

MiNEN: Mixed neuroendocrine-nonneuroendocrine neoplasms; PDNEC: Poorly differentiated neuroendocrine carcinoma; G: Grade; NET: Neuroendocrine tumor.

Citation: Elpek GO. Mixed neuroendocrine–nonneuroendocrine neoplasms of the gastrointestinal system: An update. World J Gastroenterol 2022; 28(8): 794-810
URL: https://www.wjgnet.com/1007-9327/full/v28/i8/794.htm
DOI: https://dx.doi.org/10.3748/wjg.v28.i8.794