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World J Gastroenterol. Feb 28, 2022; 28(8): 794-810
Published online Feb 28, 2022. doi: 10.3748/wjg.v28.i8.794
Table 1 Discrimination among mixed neuroendocrine-nonneuroendocrine neoplasms, neuroendocrine tumors, and carcinomas according to pathological parameters
Morphology
Dual differentiation present
Dual differentiation absent
Immunohistochemisty
Neuroendocrine markers(-)(+)(+)(+)(-)Few (+) cells1
Nonneuroendocrine markers(+)Few (+) cells(+)(+)(+)(+)
DiagnosisCarcinoma NENMiNENAmphicrine tumorCarcinomaCarcinoma