Will the collaboration of surgery and external radiotherapy open new avenues for hepatocellular carcinoma with portal vein thrombosis?

Figure 1 A case of a locally advanced hepatocellular carcinoma with portal thrombosis treated with radiotherapy. A: Multiple tumors noted in right lobe and segment 4, with a large tumor in segment 8, and involving right portal vein thrombosis; B: A dose-distribution of external radiotherapy plan. We prescribed 53 Gy/20F to gross tumor volume (red color wash in upper-left figure) with at least 42 Gy/20F were delivered to clinical target volume (green color wash in upper-left figure). Quantitative dose-histogram for specific organs is generated (upper-right figure). We planned to save at least 70% of normal liver to be irradiated less than 30 Gy; C: One year after radiotherapy and three times of transarterial chemoembolization, tumors were remised without active enhancing lesions. Liver function was maintained at Child-Pugh score A. GTV: Gross tumor volume; CTV: Clinical target volume.