Stereotactic radiotherapy and the potential role of magnetic resonance-guided adaptive techniques for pancreatic cancer

Table 2 Studies of magnetic resonance-guided radiotherapy in locally advanced pancreatic cancer

Ref.	Participants	Dosimetry	Outcome	Toxicity
Heerkens et al[25], 2018, Trial	20 (18 LAPC, 2 unresectable)	24 Gy/3 fractions	(1) Median OS 8.5 mo; (2) 69% improved QOL compared to baseline at 1 mo; and (3) 33% improved QOL compared to baseline at 12 mo	No grade ≥ 3 acute or late toxicity
Luterstein et al[8], 2018, Case Report	1 LAPC	40 Gy/5 fractions	LC at 16 mo	None
Rudra et al[31], 2019, Retrospective	44 unresectable (22 received SBRT)	30-35 Gy/5 fractions (standard-dose group, n = 6); 40-52 Gy/5 fractions (high-dose group, n = 16)	(1) 49% 2-yr OS (high-dose group); (2) 30% 2-yr OS (standard-dose group); (3) 77% 2-yr FFDF (high-dose group); and (4) 57% 2-yr FFDF (standard-dose group)	Acute: (1) 7% grade ≥ 3 GI (all in standard-dose group); and (2) 2% grade 4

LAPC: Locally advanced pancreatic Cancer; OS: Overall survival; QOL: Quality of life; LC: Local control; SBRT: Stereotactic body radiotherapy; FFDF: Freedom from distant failure; GI: Gastrointestinal.