Clinical online nomogram for predicting prognosis in recurrent hepatolithiasis after biliary surgery: A multicenter, retrospective study

Table 3 Univariable and multivariable logistic regression analyses of the risk factors for a poor prognosis in patients with recurrent hepatolithiasis

Variable	Univariable analysis		Multivariable analysis
	P value	OR (95%CI)	P value	OR (95%CI)
Sex: Female/Male	0.328	1.311 (0.762-2.257)
Age (yr): ≥ 60/< 60	0.603	1.139 (0.697-1.862)
BMI	0.068	0.921 (0.843-1.006
Abdominal pain: Yes/No	0.066	0.525 (0.264-1.043)
Fever: Yes/No	0.083	1.551 (0.945-2.547)
Jaundice: Yes/No	0.406	1.270 (0.724-2.230)
Previous operation times
2 times/1 time	0.384	1.337 (0.695-2.571)	0.299	1.451 (0.719-2.932)
3 times/1 time	< 0.001	4.840 (2.241-10.454)	< 0.001	4.573 (2.015-10.378)
≥ 4 times/1 time	0.005	7.340 (1.827-29.498)	0.018	5.741 (1.347-24.470)
Previous hepatectomy: Yes/No	0.026	1.936 (1.082-3.463)	0.144	1.642 (0.845-3.190)
Previous cholangioenterostomy: Yes/No	0.455	1.299 (0.654-2.577)
NLR: ≥ 2.462/< 2.462	0.001	2.334 (1.410-3.863)	0.022	1.915 (1.099-3.337)
PLR: ≥ 173.74/< 173.74	0.069	1.714 (0.959-3.065)
AGR: ≤ 1.5/> 1.5	0.002	2.459 (1.393-4.338)	0.033	1.949 (1.056-3.595)
TB (μmol/L): ≥ 34.2/< 34.2	0.381	1.330 (0.703-2.518)
ALT (IU/L): ≥ 50/< 50	0.664	1.117 (0.677-1.843)
AST (IU/L): ≥ 40/< 40	0.169	1.418 (0.862-2.333)
ALP (IU/L): ≥ 200/< 200	0.060	1.613 (0.981-2.654)
GGT (IU/L): ≥ 150/< 150	0.464	1.202 (0.735-1.967)
HBsAg: Positive/Negative	0.791	0.890 (0.377-2.103)
CA19-9 (U/mL): ≥ 34/< 34	0.058	1.656 (0.984-2.787)
Operation duration (h)
2-4/≤ 2	0.803	1.085 (0.572-2.057)
> 4/≤ 2	0.497	0.794 (0.408-1.545)
Liver cirrhosis: Yes/No	0.049	2.008 (1.004-4.016)	0.478	1.343 (0.595-3.034)
Hepatic atrophy: Yes/No	0.469	0.833 (0.507-1.368)
Intrahepatic stenosis: Yes/No	0.054	1.772 (0.989-3.176)
Extrahepatic stones: Yes/No	0.481	0.810 (0.450-1.456)
Hepatectomy: Yes/No	0.019	0.543 (0.326-0.904)	0.211	0.692 (0.389-1.232)
Bilateral hepatolithiasis: Yes/No	0.011	2.114 (1.183-3.775)	0.038	1.965 (1.039-3.717)
Drainage mode
Cholangioenterostomy/External T tube drainage	0.292	0.663 (0.308-1.425)
Combined drainage/External T tube drainage	0.325	1.381 (0.726-2.629)
Function of the SO
Dysfunction/Normal	0.760	1.110 (0.567-2.173)
Nonfunctional/Normal	0.051	1.791 (0.997-3.219)
Resected/Normal	0.845	0.905 (0.332-2.464)
Intraoperative bleeding (mL): ≥ 400/< 400	0.682	1.264 (0.412-3.883)
Blood transfusion: Yes/No	0.053	1.946 (0.993-3.815)
TB after operation (μmol/L): ≥ 34.2/< 34.2	0.908	1.035 (0.576-1.862)
Bile culture: Positive/Negative	0.384	1.255 (0.753-2.093)
Clavien-Dindo classification: ≥ III/< III	0.541	1.430 (0.455-4.494)
Hospitalization expenses	0.913	1.000 (1.000-1.000)
Immediate clearance: No/Yes	< 0.001	3.271 (1.874-5.711)	0.005	2.398 (1.304-4.409)
Final clearance: No/Yes	0.030	3.098 (1.117-8.595)	0.558	1.448 (0.420-4.996)

BMI: Body mass index; NLR: Neutrophil-to-lymphocyte ratio; PLR: Platelet-to-lymphocyte ratio; AGR: Albumin-to-globulin ratio; TB: Total bilirubin; ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; ALP: Alkaline phosphatase; GGT: γ-glutamyl transpeptidase; HbsAg: Hepatitis B surface antigen; CA19-9: Carbohydrate antigen19-9; SO: Sphincter of Oddi; OR: Odds ratio; CI: Confidence interval.