Connective tissue growth factor expression hints at aggressive nature of colorectal cancer

Table 5 Predictors for recurrence or mortality of colorectal cancer using extended cox-regression analysis model

Characteristics	Disease-free survival			Overall survival
	HR	95%CI	P value	HR	95%CI	P value
Age	1.66	0.4-6.4	0.45	1.03	0.9-1.1	0.32
Tumor differentiation	1.13	0.5-2.7	0.79	3.1	0.7-14.4	0.15
Tumor grade	1.12	0.4- 2.7	0.79	3.1	0.7-14.4	0.15
Depth invasion	1.6	0.8-3.2	0.18	1.91	0.6-5.7	0.30
TNM stage	2.8	1.38-5.97	0.005a	3.7	1.1-12.7	0.043a
Duke stage	9.6	2.3-40.5	0.002a	3.36	0.6-18.3	0.161
Node status	0.08	0.02-0.37	0.001a	0.25	0.04-1.5	0.139
Necrosis	0.26	0.1-0.82	0.022a	1.30	0.14-11.6	0.811
LVI	0.25	0.05-1.2	0.090	1.16	3.25e-17	0.08
PNI	0.47	0.14-1.6	0.230	0.16	0.02-0.98	0.041a
CTGF expression	0.13	0.01-1.06	0.013a	0.39	0.04-3.5	0.33

^aP < 0.05: Statistical significance. HR: Hazard ratio; CI: Confidence interval; TNM: Tumor-node-metastasis; LVI: Lymphovascular invasion; PNI: Perineural invasion; CTGF: Connective tissue growth factor.