Viral hepatitis: Innovations and expectations

Table 1 New antiviral drugs for hepatitis B

	Molecule(s)	Mechanism of action	Ref.
Entry inhibitors	Bulevirtide (Myrcludex B)	Block HBV entry into hepatocytes to protect cells not yet infected or antagonize de novo infection	[16,17]
Capsid assembly modulators	NVR 3-788; GLS4; RO7049389; JNJ-6379; JNJ-0440; ABI-H0731	Inhibition of nucleocapsid formation	[19-24]
Post-transcriptional inhibitors	ARC-520; ARC-521; ARB-1467	Induction mRNA degradation after transcription and translation prevention	[27,28]
Inhibitors of HBsAg release	REP 2165; Lenvervimab	Removal of subviral envelope particle. Neutralization activity	[29-31]
Inhibitors of cccDNA	CRISP-Cas system	Disablement of cccDNA	[32-34]

HBsAg: Hepatitis B surface antigen; cccDNA: Covalently closed circular DNA; HBV: Hepatitis B virus.