Copyright
©The Author(s) 2022.
World J Gastroenterol. Dec 28, 2022; 28(48): 6909-6921
Published online Dec 28, 2022. doi: 10.3748/wjg.v28.i48.6909
Published online Dec 28, 2022. doi: 10.3748/wjg.v28.i48.6909
Figure 1 Kelch-like ECH-associated protein 1-dependent nuclear factor-erythroid 2-related factor 2 signaling.
During oxidative stress, nuclear factor-erythroid 2-related factor 2 (NRF2) detaches from kelch-like ECH-associated protein 1 (Keap1) and translocates to the nucleus to bind the target genes. In normal conditions, NRF2 is ubiquitinylated and undergoes degradation. ARE: Antioxidant responsive element; SMaf: Small musculoaponeurotic fibrosarcoma oncogene homologue; Ub: Ubiquitin.
- Citation: Bukke VN, Moola A, Serviddio G, Vendemiale G, Bellanti F. Nuclear factor erythroid 2-related factor 2-mediated signaling and metabolic associated fatty liver disease. World J Gastroenterol 2022; 28(48): 6909-6921
- URL: https://www.wjgnet.com/1007-9327/full/v28/i48/6909.htm
- DOI: https://dx.doi.org/10.3748/wjg.v28.i48.6909