Confusion and prospects for carcinogenesis of gastric adenoma and dysplasia: What is the correct answer currently?

Figure 2 The diagram assuming the relationship between gene mutations and gastric carcinogenesis. Superficial gastric tumors can be roughly divided into two types by specific gene mutations: The APC mutation type and the TP53 mutation type. APC-type tumors have low malignancy and develop into low-grade dysplasia, whereas TP53-type tumors have high malignancy and are considered cancerous even if small. JGCA: Japanese Gastric Cancer Association; HGD: High-grade dysplasia; LGD: Low-grade dysplasia.