Confusion and prospects for carcinogenesis of gastric adenoma and dysplasia: What is the correct answer currently?

Table 2 Brief summary of The Cancer Genome Atlas classification

Type	Chromosomal instability	EBV	Microsatellite instability	Genomically stable
Percentage	50%	9%	21%	20%
Profile of patients		Male prevalence	Elderly age	Younger age
Location	GEJ, cardia	Corpus or fundus	Antrum	Distal location
Lauren type	Intestinal		Intestinal	Poorly cohesive
Other pathological feature	DNA aneuploidy	Carcinoma with lymphoid stroma
Prognosis			Favorable	Worst
Genetic features	TP53 mutation	Extensive DNA promoter methylation	MLH1 promoter hypermethylation	Low copy number alterations and mutational burden
	Amplification of TKR	CDKN2A promoter hypermethylation	High mutational burden	ARID1, RHOA, CDH1 mutations
		PIK3CA, ARID1A, BCOR mutations		CLDN18-ARHGAP26 fusion in 15%

TCGA: The Cancer Genome Atlas; EBV: Eptein-Barr virus; GEJ: Esophagogastric junction.