Dickkopf-related protein 1/cytoskeleton-associated protein 4 signaling activation by Helicobacter pylori-induced activator protein-1 promotes gastric tumorigenesis via the PI3K/AKT/mTOR pathway

Figure 1 Comparison of differentially expressed genes between primary gastric cancer cells with and without Helicobacterpylori infection. A: Venn diagram of differentially expressed genes (>DEGs); B: DEGs heatmap analysis by R heatmap package. Asterisks indicate the genes investigated in this study; C: Gene Ontology analysis of the DEGs; D: Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis of the DEGs; E: Protein-protein interaction network of the DEGs; F: Gene set enrichment analysis (GSEA) enrichment analyses of the DEGs with GSEA version 4.1.0. Con: Control; GZ7: Helicobacter pylori GZ7. TNF: Tumor necrosis factor; FOSL1: Fos-like antigen-1; DKK1: Dickkopf-related protein 1.