Interleukin-34 deficiency aggravates development of colitis and colitis-associated cancer in mice

Figure 2 Interleukin-34 deficiency aggravates acute colitis induced by dextran sodium sulfate. A: Schematic of the design of acute dextran sodium sulfate (DSS)-induced colitis model. IL-34^-/- and WT mice were fed with a 3% DSS solution in drinking water for 7 d and then sacrificed (n = 6 or 7 per group); B: Body weight was represented as a percentage of starting weight in IL-34^-/- and WT mice after administration of 3% DSS (n = 6 or 7 per group); C: The clinical score of IL-34^-/- and WT mice treated with 3% DSS (n = 6 or 7 per group). Data depict the mean ± SD; D: Kaplan-Meier survival curves were plotted in IL-34^-/- and WT mice administrated with 3% DSS for 15 d (n = 10 per group); E and F: Colon length was measured in IL-34^-/- and WT mice fed with 3% DSS for 7 d (n = 6 or 7 per group). DSS: Dextran sodium sulfate; IL-34: Interleukin-34; WT: Wild-type. Data depict the mean ± SD. ^aP < 0.05, ^bP < 0.01, ^cP < 0.005, ^dP < 0.001.