Interleukin-34 deficiency aggravates development of colitis and colitis-associated cancer in mice

Figure 1 Interleukin-34 is elevated in colitis and colitis-related cancers. A: Interleukin-34 (IL-34) relative mRNA expression in stomach, jejunum, ileum and colon in wild-type mice (C57BL/6J) (n = 6); B and C: The dynamic of IL-34 expression in dextran sodium sulfate (DSS)-induced colitis and azoxymethane-DSS-induced colorectal cancer in wild-type mice (n = 6 per group); representative IL-34 immunohistochemical staining for healthy control, acute colitis, chronic colitis and colorectal cancer mice (B); the percentage of IL-34-positive cells per high-power field were quantified in colonic tissue of four groups of mice (n = 6 per group) (C). AOM: Azoxymethane; CRC: Colorectal cancer; DSS: Dextran sodium sulfate; IL-34: Interleukin-34. Scale bars = 100 μm. Data depict the mean ± SD. ^aP < 0.05, ^bP < 0.01, ^cP < 0.005, ^dP < 0.001.