3,6-dichlorobenzo[b]thiophene-2-carboxylic acid alleviates ulcerative colitis by suppressing mammalian target of rapamycin complex 1 activation and regulating intestinal microbiota

Figure 7 Effects of 3,6-dichlorobenzo[b]thiophene-2-carboxylic acid treatment on the species composition. A: Taxonomic analysis at the phylum level; B: BT2 treatment alters the Firmicutes/Bacteroidetes value in each group; C: Taxonomic analysis at the family level; D: Abundance of Prevotellaceae; E: Abundance of Clostridiaceae; F: Abundance of Oscillospiraceae; G: Abundance of Enterobacteriaceae; H: Abundance of Escherichia-Shigella. ^dP < 0.05, ^eP < 0.01, and ^fP < 0.001 vs the DSS group; ^aP < 0.05, ^bP < 0.01, and ^cP < 0.001 vs the control group. The data are shown as the mean ± SD (n = 8). DSS: Dextran sodium sulfate; BT2: 3,6-dichlorobenzo[b]thiophene-2-carboxylic acid.