3,6-dichlorobenzo[b]thiophene-2-carboxylic acid alleviates ulcerative colitis by suppressing mammalian target of rapamycin complex 1 activation and regulating intestinal microbiota

Figure 6 Effects of 3,6-dichlorobenzo[b]thiophene-2-carboxylic acid treatment on the overall structure of gut microbiota. A: The Venn diagram depicts the overlap of operational taxonomic units in each group; B: Chao1 index from fecal samples; C: Shannon index from fecal samples; D: The dilution curve indicates the rationality of the amount of sequencing data; E: Nonmetric multidimensional scaling analysis plot of fecal microbiota of each group. ^eP < 0.01 and ^fP < 0.001 vs the dextran sodium sulfate group; ^bP < 0.01 and ^cP < 0.001 vs the control group. The data are shown as the mean ± SD (n = 8). DSS: Dextran sodium sulfate; OUT: Operational taxonomic units; BT2: 3,6-dichlorobenzo[b]thiophene-2-carboxylic acid.