3,6-dichlorobenzo[b]thiophene-2-carboxylic acid alleviates ulcerative colitis by suppressing mammalian target of rapamycin complex 1 activation and regulating intestinal microbiota

Figure 2 3,6-dichlorobenzo[b]thiophene-2-carboxylic acid reduced the inflammatory cytokine levels in serum. The contents of interleukin (IL)-6, IL-9, IL-2 and IL-10 in serum were detected by flow cytometry. A: IL-6; B: IL-9; C: IL-2; D: IL-10. ^dP < 0.05, ^eP < 0.01, and ^fP < 0.001 vs the dextran sodium sulfate group; ^bP < 0.01 and ^cP < 0.001 vs the control group. The data are shown as the mean ± SD (n = 4). DSS: Dextran sodium sulfate; SASP: Salazosulfapyridine; BT2: 3,6-dichlorobenzo[b]thiophene-2-carboxylic acid.