3,6-dichlorobenzo[b]thiophene-2-carboxylic acid alleviates ulcerative colitis by suppressing mammalian target of rapamycin complex 1 activation and regulating intestinal microbiota

Figure 1 3,6-dichlorobenzo[b]thiophene-2-carboxylic acid improved colon inflammation in dextran sodium sulfate-treated mice. A: Changes in the body weight of mice; B: Disease activity index of each group of mice on day 8 (n = 5); C: The colon length of each group of mice was measured; D: Macroscopic observation of colons; E: Representative hematoxylin and eosin staining images of colon sections (200 × magnification); F: Injury scores. ^eP < 0.01 and ^fP < 0.001 vs the dextran sodium sulfate group; ^cP < 0.001 vs the control group. The data are shown as the mean ± SD (n = 5-8). DSS: Dextran sodium sulfate; SASP: Salazosulfapyridine; BT2: 3,6-dichlorobenzo[b]thiophene-2-carboxylic acid.