Best therapy for the easiest to treat hepatitis C virus genotype 1b-infected patients

doi:10.3748/wjg.v28.i45.6380

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World Journal of Gastroenterology

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1007-9327

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World J Gastroenterol. Dec 7, 2022; 28(45): 6380-6396
Published online Dec 7, 2022. doi: 10.3748/wjg.v28.i45.6380

Table 4 The overall treatment effectiveness and according to treatment regimens in relation to different risk factors among the studied patients (per protocol analysis)

Parameter	Whole population	Females	Males	F4	T-ex	History of hepatic decompensation	≥ 70-year-old	eGFR ≤ 60 mL/min	Obese¹	HIV+
All regimens	10903/11112 (98.1)	5891/5969 (98.7)	5012/5143 (97.5)	2590/2678 (96.7)	2726/2795 (97.5)	319/336 (94.9)	1490/1509 (98.7)	281/284 (98.9)	1880/1923 (97.8)	327/341 (95.9)
ASV + DCV	119/132 (90.2)	72/79 (91.1)	47/53 (88.7)	47/55 (85.5)	40/47 (85.1)	0/1 (0)	22/24 (91.7)	5/5 (100)	26/28 (92.9)	1/1 (100)
LDV/SOF ± RBV	2534/2582 (98.1)	1381/1398 (98.8)	1153/1184 (97.4)	679/707 (96)	680/696 (97.7)	173/181 (95.6)	386/389 (99.2)	67/67 (100)	446/459 (97.2)	103/107 (96.3)
OBV/PTV/r + DSV ± RBV	3563/3627 (98.2)	1949/1973 (98.8)	1614/1654 (97.6)	969/992 (97.7)	1490/1516 (98.3)	72/74 (97.3)	397/403 (98.5)	80/82 (97.6)	602/611 (98.5)	26/28 (92.9)
GZR/EBR ± RBV	2179/2216 (98.3)	1201/1215 (98.8)	978/1001 (97.7)	362/372 (97.3)	291/297 (98)	19/20 (95)	397/401 (99)	87/88 (98.9)	380/389 (97.7)	48/48 (100)
GLE/PIB	1625/1643 (98.9)	869/874 (99.4)	756/769 (98.3)	264/268 (98.5)	112/114 (98.2)	12/12 (100)	147/150 (98)	24/24 (100)	267/267 (100)	72/76 (94.7)
GLE/PIB + SOF + RBV	3/3 (100)	1/1 (100)	2/2 (100)	1/1 (100)	3/3 (100)	-	-	-	1/1 (100)	-
SOF/VEL ± RBV	857/884 (96.9)	409/419 (97.6)	448/465 (96.3)	260/275 (94.5)	91/101 (90.1)	40/44 (90.9)	138/139 (99.3)	16/16 (100)	158/167 (94.6)	74/78 (94.9)
VOX/VEL/SOF	9/9 (100)	2/2 (100)	7/7 (100)	3/3 (100)	7/7 (100)	-	3/3 (100)	-	-	3/3 (100)

¹Body mass index > 30 kg/m².

Data are presented as number/total number of patients (percentage). ASV: Asunaprevir; DCV: Daclatasvir; DSV: Dasabuvir; EBR: Elbasvir; eGFR: Estimated glomerular filtration rate; F: Fibrosis; GLE: Glecaprevir; GZR: Grazoprevir; HIV: Human immunodeficiency virus; LDV: Ledipasvir; OBV: Ombitasvir; PIB: Pibrentasvir; PP: Per protocol; PTV/r: Paritaprevir; RBV: Ribavirin; SOF: Sofosbuvir; SVR: Sustained virological response; T-ex: Treatment-experience; VEL: Velpatasvir; VOX: Voxilaprevir.

Citation: Zarębska-Michaluk D, Brzdęk M, Jaroszewicz J, Tudrujek-Zdunek M, Lorenc B, Klapaczyński J, Mazur W, Kazek A, Sitko M, Berak H, Janocha-Litwin J, Dybowska D, Supronowicz Ł, Krygier R, Citko J, Piekarska A, Flisiak R. Best therapy for the easiest to treat hepatitis C virus genotype 1b-infected patients. World J Gastroenterol 2022; 28(45): 6380-6396
URL: https://www.wjgnet.com/1007-9327/full/v28/i45/6380.htm
DOI: https://dx.doi.org/10.3748/wjg.v28.i45.6380