Liver injury induced by COVID 19 treatment – what do we know?

Table 1 Clinical evidence of coronavirus disease 2019-mediated impact on various biochemical indexes

Biochemical parameters	Observed range (minimum to maximum)	Inference	Ref.
Hepatobiliary function markers
Alanine aminotransferase	15-107 U/L (7590 U/L for one patient with severe hepatitis)	Elevated serum levels	[8-11]
Aspartate transaminase	15-132 U/L (1445 U/L for one patient with severe hepatitis)	Elevated serum levels	[8-11]
Alkaline phosphate	48-118 U/L	Elevated serum levels	[8,10,11]
Total bilirubin	5.0-33.7 μmol/L	Elevated serum levels	[8-11]
Gamma-glutamyl transferase	15-161 U/L	Elevated in severe cases	[8-11]
Albumin	4-45 g/L	Reduced serum levels	[8-11]
Lactate dehydrogenase	124.8-716 U/L	Elevated serum levels	[8,10,11]
Inflammatory markers
Lymphocytes count	(0.64 × 109)-(1.10 ×0 109)/L	Reduced serum levels	[10]
C-Reactive protein	6.9-88.6 mg/L	Elevated serum levels	[10]
Interleukin-6	28.72 ng/L	Elevated serum levels	[10,33]
CD8+ T cell count	(220 × 107)-(220 × 109) cells/L	Reduced blood levels	[10]
Erythrocyte sedimentation rate	Maximum 58 mm/h	Elevated	[10]
Other markers
D-dimer levels	0.20-4.55 μg/mL	Elevated plasma levels	[32,33]
Fibrinogen levels	220.0-528.0 mg/dL	Elevated plasma levels	[31,33]