Salvia miltiorrhiza extract may exert an anti-obesity effect in rats with high-fat diet-induced obesity by modulating gut microbiome and lipid metabolism

Figure 8 Lipidomics analysis and associations of gut microbial species with environmental factors. A: Numbers of differential metabolites between the control and high-fat diet (HFD) groups, HFD and Sal_L groups, HFD and Sal_M groups, and HFD and Sal_H groups (Venn diagram); B: Hierarchical clustering of metabolites in Control, HFD, Sal_L, Sal_M, and Sal_H groups; C: Heatmap of the VIP expression profile of the metabolites between control and HFD groups; D: Heatmap of the VIP expression profile of the metabolites between HFD and Sal_M groups; E: KEGG pathway enrichment; F: Spearman’s correlation between metabolites and gut microbiota; G: Correlation between free fatty acids, weight, body fat index, glucose, and microbial flora structure displayed by distance-based redundancy analysis (db-RDA analysis); H: Spearman’s correlation between cAMP, PKA, HSL, and gut microbiota. ^aP < 0.05, ^bP < 0.01, or ^cP < 0.001.