Clinical value of predictive models based on liver stiffness measurement in predicting liver reserve function of compensated chronic liver disease

doi:10.3748/wjg.v28.i42.6045

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Nov 14, 2022 (publication date) through Mar 7, 2025

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Retrospective Cohort Study

World J Gastroenterol. Nov 14, 2022; 28(42): 6045-6055
Published online Nov 14, 2022. doi: 10.3748/wjg.v28.i42.6045

Table 1 Comparison of demographic and clinical characteristics of chronic liver disease patients in the training cohort and validation cohort

	Validation cohort, n = 132	Training cohort, n = 360	P value
Gender (male/female, n)	90/42	260/100	0.381
Age (yr)	54.84 ± 27.70	48.71 ± 13.34	0.001
Etiology			0.097
HBV	111	278
Others	21	82
HCC (n)	42	63	0.001
HB (g/dL)	14.28 ± 10.86	13.71 ± 2.16	0.346
PLT (× 10⁹/L)	174.96 ± 83.93	170.95 ± 74.69	0.610
PT (s)	13.21 ± 1.66	12.84 ± 1.67	0.030
APTT (s)	33.28 ± 7.73	32.54 ± 6.14	0.273
INR	1.16 ± 0.16	1.09 ± 0.16	0.000
AST (U/L)	72.14 ± 78.19	86.16 ± 135.81	0.264
ALT (U/L)	106.35 ± 166.60	136.73 ± 247.37	0.192
ALB (g/L)	38.03 ± 5.22	40.03 ± 5.08	0.000
TBIL (μmol/L)	28.29 ± 31.05	19.94 ± 16.99	0.000
CHE (U/L)	6163.11 ± 2647.19	6748.44 ± 2127.44	0.015
ALP (U/L)	118.60 ± 95.93	179.64 ± 721.94	0.334
GGT (U/L)	128.91 ± 201.79	116.89 ± 188.75	0.539
GLO (g/L)	28.70 ± 4.81	29.02 ± 5.19	0.534
Cr (μmol/L)	65.36 ± 23.23	65.68 ± 15.38	0.860
MELD	8.14 ± 3.46	7.80 ± 2.56	0.241
ALBI	-2.36 ± 0.54	-2.60 ± 0.48	0.000
PTAR	0.31 ± 0.07	0.28 ± 0.07	0.000
ICGR15 (%)	11.55 ± 11.82	8.16 ± 8.56	0.000
LSM (kPa)	19.54 ± 18.28	16.34 ± 16.62	0.066

HBV: Hepatitis B virus; HCC: Hepatocellular carcinoma; HB: Hemoglobin; PLT: Platelet count; PT: Prothrombin time; APTT: Active prothrombin time; INR: International normalized ratio; AST: Aspartate transaminase; ALT: Alanine aminotransaminase; ALB: Albumin; TBIL: Total bilirubin; CHE: Cholinesterase; ALP: Alkaline phosphatase; GGT: Gamma-glutamyltransferase; GLO: Globulin; Cr: Creatinine; MELD: Model for end-stage liver disease; ALBI: Albumin-bilirubin grade; PTAR: Prothrombin time international normalized ratio to albumin ratio; ICGR15: Indocyanine green retention rate at 15 min; LSM: Liver stiffness measurement.

Citation: Lai RM, Wang MM, Lin XY, Zheng Q, Chen J. Clinical value of predictive models based on liver stiffness measurement in predicting liver reserve function of compensated chronic liver disease. World J Gastroenterol 2022; 28(42): 6045-6055
URL: https://www.wjgnet.com/1007-9327/full/v28/i42/6045.htm
DOI: https://dx.doi.org/10.3748/wjg.v28.i42.6045