Liver transplantation is beneficial regardless of cirrhosis stage or acute-on-chronic liver failure grade: A single-center experience

doi:10.3748/wjg.v28.i40.5881

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Oct 28, 2022 (publication date) through Dec 24, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Observational Study

World J Gastroenterol. Oct 28, 2022; 28(40): 5881-5892
Published online Oct 28, 2022. doi: 10.3748/wjg.v28.i40.5881

Table 1 Patient characteristics (n = 235)

	CC, n = 11 (4.5%)	DC, n= 129 (52.9%)	ACLF, n = 95 (38.9%)	P value
Male gender, n (%)	6 (54.5)	64 (49.6)	47 (49.5)	0.95
Age, yr	57.0 (53.0-59.0)^a	52.0 (43.0-61.0)^c	50.0 (37.0-59.0)^a^,^c	0.02
Liver cirrhosis etiology, n (%)
Autoimmune	1 (9.1)^a	36 (27.9)^c	42 (44.2)^a^,^c	< 0.01
HCV	8 (72.7)^a^,^b	42 (32.6)^b^,^c	13 (13.7)^a^,^c	< 0.0001
Alcoholic liver disease	1 (9.1)	11 (8.5)	9 (9.5)	0.93
NASH	0 (0.0)	7 (5.4)	6 (6.3)	0.88
Cryptogenic	1 (9.1)	22 (17.1)	18 (18.9)	0.76
Other¹	0 (0.0)	11 (8.5)	7 (7.4)	0.84
Comorbidities, n (%)
Type 2 diabetes mellitus	3 (27.3)	22 (17.1)	13 (13.7)	0.44
Primary hypertension	2 (18.2)	20 (15.5)	6 (6.3)	0.06
Pre-transplant clinical data
MELD-Na	11 ± 3^a^,^b	19 ± 4^b^,^c	25 ± 6^a^,^c	< 0.0001
Total bilirubin (mg/dL)	1.18 (1.03-1.45)^a^,^b	3.39 (2.3-5.46)^b^,^c	7.70 (4.14-16.63)^a^,^c	< 0.0001
INR	1.1 (1.1-1.2)^a^,^b	1.5 (1.3-1.7)^b	1.5 (1.3-2.0)^a	< 0.0001
Serum creatinine (mg/dL)	0.67 (0.57-0.71)^a	0.73 (0.61-0.88)^c	0.97 (0.75-1.35)^a^,^c	< 0.0001
Leukocyte count (× 10⁹/L)	2.9 (2.4-3)^a	4 (3.1-5)^c	5.4 (3.8-6.8)^a^,^c	< 0.0001
Disease manifestations², n (%)
Clinical ascites	0 (0.0)^a^,^b	88 (68.2)^b^,^c	88 (92.6)^a^,^c	< 0.0001
Encephalopathy	0 (0.0)^a^,^b	69 (53.5)^b^,^c	80 (84.2)^a^,^c	< 0.0001
Grade 3-4 encephalopathy (West- Haven)	0 (0.0)^a^,^b	7 (5.4)^b^,^c	37 (38.9)^a^,^c	< 0.0001

¹Includes secondary biliary cirrhosis, drug-induced liver injury, and congenital liver diseases.

²Disease manifestations during the whole clinical course until liver transplantation.

Comparisons between groups are shown with superscript letters.

^aSignificant difference between CC and ACLF.

^bSignificant difference between CC and DC.

^cSignificant difference between DC and ACLF.

ACLF: Acute-on-chronic liver failure; CC: Compensated cirrhosis; DC: Decompensated cirrhosis; HCV: Hepatitis C virus; INR: International normalized ratio; MELD Na: Model for End-Stage Liver Disease-Sodium; NASH: Non-alcoholic steatohepatitis.

Citation: Cervantes-Alvarez E, Vilatoba M, Limon-de la Rosa N, Mendez-Guerrero O, Kershenobich D, Torre A, Navarro-Alvarez N. Liver transplantation is beneficial regardless of cirrhosis stage or acute-on-chronic liver failure grade: A single-center experience. World J Gastroenterol 2022; 28(40): 5881-5892
URL: https://www.wjgnet.com/1007-9327/full/v28/i40/5881.htm
DOI: https://dx.doi.org/10.3748/wjg.v28.i40.5881