Fibrinogen-like protein 2 deficiency inhibits virus-induced fulminant hepatitis through abrogating inflammatory macrophage activation

Figure 1 Fibrinogen-like protein 2 was expressed on proinflammatory macrophages in patients with hepatitis B virus-associated liver failure. A: Representative image of liver sections (200×) subjected to Hematoxylin and eosin staining (H&E); Black circles point to transparent necrosis, red circles point to infiltrating leukocytes; B: Calculation of CD68+ macrophages at periportal and lobular areas; C: Immunofluorescence against CD68, S100A9 on liver sections (200×) from patients of hepatitis B virus-associated acute chronic-on liver failure (acute-on-chronic liver failure (ACLF), n = 7) and healthy controls (n = 3); D: Immunofluorescence against S100A9 and fibrinogen-like protein 2 on liver sections (200×) from ACLF patients (n = 7) and healthy controls (n = 3), representative images on the left and statistical columns on the right. Data are expressed as mean ± SD.